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The primetime Week 13 Monday Night Football matchup features the Buffalo Bills (8-3) and San Francisco 49ers (5-6). Below, we preview the Bills-49ers betting odds and lines and make our NFL picks and predictions.
For the Bills, it is a road game, but it is not in Santa Clara, Calif., where the 49ers normally play. Because Santa Clara health protocols will not allow sports to be played there, the 49ers are in Arizona. Kickoff will be at 8:15 p.m. at State Farm Stadium in Glendale.
Also see:Bills vs. 49ers prop bet predictions
Bills vs. 49ers: Betting odds, spread and lines
Odds via BetMGM; access USA TODAY Sports' betting odds for a full list. Lines last updated 8:20 a.m. ET.
Money line: Bills -105 (bet $105 to win $100) | 49ers -112 (bet $112 to win $100)Against the spread/ATS: Bills +1 (-115) | 49ers -1 (-105)Over/Under: 47.5 (O: -105 | U: -115)Special Monday Night Football Promotion!
Bet $1 on either the Buffalo Bills or San Francisco 49ers money line, WIN an additional $100 (in free bets) if either team scores a touchdown. Place your legal, online NFL bets in CO, IN, NJ, TN and WV at BetMGM.
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Bills vs. 49ers: Game notes
Buffalo already lost this season at State Farm Stadium to the Arizona Cardinals on a last-second Hail Mary.The Bills have won four of their last five games, the only loss being in Arizona.San Francisco is 1-4 as the home team.49ers QB Nick Mullens is 2-3 as a starter this year. He has 1,642 passing yards, 6 touchdowns and 7 interceptions in seven total games.Bills QB Josh Allen has completed 68.8% of his passes this season for 3,028 yards, 22 touchdowns and 8 interceptions.Bills vs. 49ers: Key injuries
49ers
CB Emmanuel Moseley (hamstring) questionableCB K'Waun Williams (ankle) outBills 49ers Odds
Bills vs. 49ers: Odds, betting lines, predictions and picks
Prediction
Bills 27, 49ers 23
Money line (?)
This is a true tossup with the line, so there is value on both sides. The 49ers are coming off a big win last week over the Los Angeles Ramsand are threatening to get back into the playoff race; however, the Bills have been on a roll, losing only once in their last five games.
The Niners have had to move all their operations to Arizona so they are not completely settled in. That will show in the game. Take the BILLS (-105).
Against the spread (?)
With a one-point spread, the only way to go is with the winner you take on the money line. Otherwise, you're predicting a tie (virtually impossible) or negating the money line bet.
The San Francisco defense is solid, allowing only 315.2 yards per game and 23.1 points per game, but Buffalo's offense is explosive. The Bills have five games of scoring at least 30 points and seven of at least 27. In Mullens' five starts for the Niners, they have scored 20 points only twice. Take the BILLS +1 (-115).
Over/Under (?)
The Bills are 7-3-1 O/U, while the Niners are 5-6 O/U. Three of the Bills' last four games hit the Over. Both teams should score roughly their season average (27.2 for the Bills, 23.7 for the 49ers) and should go Over the projected total. Take OVER 47.5 (-105).
Want action on this NFL game? Sign up and bet at BetMGM. If you're looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.
Sf 49ers Game Odds
Also see:
PFF predicts Buffalo will re-sign Matt Milano (Bills Wire)Sherman believes re-signing with San Francisco is unlikely (Niners Wire)
Odds via BetMGM; access USA TODAY Sports' betting odds for a full list. Lines last updated 8:20 a.m. ET.
Money line: Bills -105 (bet $105 to win $100) | 49ers -112 (bet $112 to win $100)Against the spread/ATS: Bills +1 (-115) | 49ers -1 (-105)Over/Under: 47.5 (O: -105 | U: -115)Special Monday Night Football Promotion!
Bet $1 on either the Buffalo Bills or San Francisco 49ers money line, WIN an additional $100 (in free bets) if either team scores a touchdown. Place your legal, online NFL bets in CO, IN, NJ, TN and WV at BetMGM.
New customer offer, terms and conditions apply. Bet now!
Bills vs. 49ers: Game notes
Buffalo already lost this season at State Farm Stadium to the Arizona Cardinals on a last-second Hail Mary.The Bills have won four of their last five games, the only loss being in Arizona.San Francisco is 1-4 as the home team.49ers QB Nick Mullens is 2-3 as a starter this year. He has 1,642 passing yards, 6 touchdowns and 7 interceptions in seven total games.Bills QB Josh Allen has completed 68.8% of his passes this season for 3,028 yards, 22 touchdowns and 8 interceptions.Bills vs. 49ers: Key injuries
49ers
CB Emmanuel Moseley (hamstring) questionableCB K'Waun Williams (ankle) outBills 49ers Odds
Bills vs. 49ers: Odds, betting lines, predictions and picks
Prediction
Bills 27, 49ers 23
Money line (?)
This is a true tossup with the line, so there is value on both sides. The 49ers are coming off a big win last week over the Los Angeles Ramsand are threatening to get back into the playoff race; however, the Bills have been on a roll, losing only once in their last five games.
The Niners have had to move all their operations to Arizona so they are not completely settled in. That will show in the game. Take the BILLS (-105).
Against the spread (?)
With a one-point spread, the only way to go is with the winner you take on the money line. Otherwise, you're predicting a tie (virtually impossible) or negating the money line bet.
The San Francisco defense is solid, allowing only 315.2 yards per game and 23.1 points per game, but Buffalo's offense is explosive. The Bills have five games of scoring at least 30 points and seven of at least 27. In Mullens' five starts for the Niners, they have scored 20 points only twice. Take the BILLS +1 (-115).
Over/Under (?)
The Bills are 7-3-1 O/U, while the Niners are 5-6 O/U. Three of the Bills' last four games hit the Over. Both teams should score roughly their season average (27.2 for the Bills, 23.7 for the 49ers) and should go Over the projected total. Take OVER 47.5 (-105).
Want action on this NFL game? Sign up and bet at BetMGM. If you're looking for more sports betting picks and tips, visit SportsbookWire.com. Please gamble responsibly.
Sf 49ers Game Odds
Also see:
PFF predicts Buffalo will re-sign Matt Milano (Bills Wire)Sherman believes re-signing with San Francisco is unlikely (Niners Wire)Sf 49ers Odds To Win Super Bowl
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